Jian-Hua Xie
author:张玮光  Release time:2017-10-17   Browse times:95



 Name: Jian-Hua Xie

 Special Talent: National Science Fund for Distinguished Young Scholars

 Subject: Organic chemistry

 Address: Institute of Elemento-Organic Chemistry and State Key Lab of Elemento-Organic Chemistry, Nankai University

 Telephone: 022-23508049;13820987446

 Fax: 022-23506177

 E-Mail: jhxie@nankai.edu.cn

 Website address: http://zhou.nankai.edu.cn/



 Research Interest:

 The main emphasis of my research is the discovery and development of new catalytic synthetic methods with particular interest in asymmetric catalysis, the asymmetric total synthesis of various biologically active natural products and structural analogues, as well as the design and synthesis of new highly efficient chiral ligands and catalysts for asymmetric reactions.



 20072008 Postdoctoral Fellow, University of Maryland, USA, (with Prof. Micheal P. Doyle)

 2000-2003 Ph.D. (Chemistry), Nankai University, (with Prof. Qi-Lin Zhou)

 1994-1997 M.Sc. (Chemistry), Nankai University, (with Prof. Tian-Lin Liu)

 1990-1992 B.Sc. (Chemistry), Sichuan Teachers College


 2011-present Professor, Nankai University

 2006—2011 Associate Professor, Nankai University

 2003—2005 Assistance Professor, Nankai University


 Honors and Awards:

 2013 Tianjin Natural Science Award (The First-Rank)

 2013 Award for Outstanding Young Scientists (National Natural Science Foundation of China)

 2012 Thieme Chemistry Journals Award

 2008 New Century Excellent Talents Project (Ministry of Education, China)

 2007 Tianjin Natural Science Award (The First-Rank)


 Selected publications:

 1) Liu, Chong; Xie, Jian-Hua*; Li, Ya-Li; Chen, Ji-Qaing; Zhou, Qi-Lin*, Asymmetric hydrogenation of ,-disubstituted cycloketones through dynamic kinetic resolution: An efficient construction of chiral diols with three contiguous stereocenters, Angew. Chem. Int. Ed. 2013, 52, 593–596.

 2) Yang, Xiao-Hui; Xie, Jian-Hua*; Liu, Wei-Peng; Zhou, Qi-Lin*, Catalytic asymmetric hydrogenation of -ketoesters: Highly efficient approach to chiral 1,5-diols, Angew. Chem. Int. Ed. 2013, 52, 7833–7836.

 3) Cheng, Li-Jie; Xie, Jian-Hua*; Chen, Yong; Wang, Li-Xin; Zhou, Qi-Lin*, Enantioselective total synthesis of Δ8-THC and Δ9-THC via catalytic asymmetric hydrogenation and SNAr cyclization, Org. Lett. 2013, 15, 764–767.

 4) Xie, Jian-Hua*; Liu, Xiao-Yan; Yang, Xiao-Hui; Xie, Jian-Bo; Wang, Li-Xin; Zhou, Qi-Lin*, Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of -aryl--ketoesters, Angew. Chem. Int. Ed. 2012, 51, 201–203.

 5) Zhang, Qian-Qian; Xie, Jian-Hua*; Yang, Xiao-Hui; Xie, Jian-Bo; Zhou, Qi-Lin*, Iridium-catalyzed asymmetric hydrogenation of -substituted ,-unsaturated acyclic ketones: Enatioselective total synthesis of (–)-Mesember, Org. Lett. 2012, 14, 6158–6161.

 6) Chen, Ji-Qiang; Xie, Jian-Hua*; Bao, Deng-Hui; Liu, Sheng; Zhou, Qi-Lin*, Total synthesis of (–)-Galanthamine and (–)-Lycoramine via catalytic asymmetric hydrogenation and intromolecular reductive Heck cyclization, Org. Lett. 2012, 14, 2714–2717.

 7) Xie, Jian-Hua*; Guo, Lu-Chuan; Yang, Xiao-Hui; Wang, Li-Xin; Zhou, Qi-Lin*, Enantioselective synthesis of 2,6-cis-disubstituted tetrahydropyrans via a tandem catalytic asymmetric hydrogenation/oxa-Michael cyclization: An efficient approach to (–)-Centrolobine, Org. Lett. 2012, 14, 4758–4761.

 8) Cheng, Li-Jie; Xie, Jian-Hua*; Wang, Li-Xin; Zhou, Qi-Lin*, Enantioselective synthesis of (–)-CP-55940 via ruthenium catalyzed asymmetric hydrogenation, Adv. Synth. Catal. 2012, 354, 1105–1113.

 9) Xie, Jian-Hua*; Liu, Xiao-Yan; Xie, Jian-Bo; Wang, Li-Xin; Zhou, Qi-Lin*, An additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of ketones, Angew. Chem. Int. Ed. 2011, 50, 7329–7332.

 10) Xie, Jian-Bo; Xie, Jian-Hua*; Liu, Xiao-Yan; Kong, Wei-Ling; Li, Sheng; Zhou, Qi-Lin*, Highly enantioselective hydrogenation of -arylmethylene cycloalkanones catalyzed by iridium complexes of chiral spiro aminophosphine ligands, J. Am. Chem. Soc. 2010, 132, 4538–4539.