席真

Zhen Xi (席 真) 

Pesticide Science and Chemical Biology 
Tel & Fax: +86-22-23504782 
Email: zhenxi@nankai.edu.cn

Research Interest 

Design, synthesis and action mechanism of bioactive small molecules and the biochemistry of their targets

1. Non Watson-Crick DNA structure recognition and its application

2. Biorational design and synthesis of bioactive agents

3. Molecular basis of pesticide action

History

• 1983 BS Central China Normal University

• 1988 MS Nankai University

• 1994 PhD Uppsala University, Sweden

• 1994-1997 Research Fellow, Harvard Medical School

• 1997-2001 Research Associate, Harvard Medical School

• 2001- Professor, IEOC, College of Chemistry, NKU

Selected publications

1. Yuan-xiang Li, Yan-ping Luo, Zhen Xi, Cong-wei Niu, Yan-zhen He, Guang-fu Yang “Design and Syntheses of Novel Phthalazin-1(2 H)-one Derivatives as Acetohydroxyacid Synthase Inhibitors” J. Agric. Food Chem. 2006, 54, 9135-9139.

2. Zhen Xi, Ruoyu Zhang, Zhihong Yu, Di Ouyang “The interaction between tylophorine B and TMV RNA” Bioorganic & Medicinal Chemistry Letters, 2006, 16, 4300.

3. Zhen Xi, Zhihong Yu, Congwei Niu, Shurong Ban, Guangfu Yang, “Development of a general quantum-chemical descriptor for steric effects: density functional theory based QSAR study of herbicidal sulfonylurea analogues” J. Computational Chem. 2006, 27, 1571.

4. L. S. Kappen, Zhen Xi, G. B. Jones, and I. H. Goldberg "Stimulation of DNA Strand Slippage Synthesis by a Bulge Binding Synthetic Agent" Biochemistry 2003, 42, 2166-2173.

5. Zhen Xi, G.. S. Hwang, I. H. Goldberg, J. L. Harris, W. T. Pennington, F. S. Fouad, G. Qabaja, J. M. Wright, and G. B. Jones "Targeting DNA bulged microenvironments with synthetic agents: Lessons from a natural product." Chemistry & Biology 2002, 9, 925-931.

Honors and Awards 

Eli Liley Research Excellence Award (China), 2006